| ncRNA name | hsa-miR-655 |
| ncRNA Category | miRNA |
| Disease name | retinoblastoma (RB) |
| Species | Homo sapiens |
| Tissues/Cell_line | RB samples, normal retina samples; RB cell line: Y79, SO-RB50 and WERI-RB1 |
| Methods | qRT-PCR, MTT assay, transwell assay, flow cytometry, luciferase report assay, Western blot |
| Expression pattern | down-regulated |
| Functional description | miR-655 is downregulated in RB tissues and cell lines. Upregulation of miR-655 inhibits cell proliferation, invasion and increases apoptosis of RB cells. PAX6 is a direct target of miR-655 in RB. PAX6 is upregulated in RB tissues and inversely correlated with miR-655 expression. |
| PubMed ID | 29436689 |
| Year | 2018 |
| Title | MicroRNA-655 attenuates the malignant biological behaviours of retinoblastoma cells by directly targeting PAX6 and suppressing the ERK and p38 MAPK signalling pathways. |
| Drug-related ncRNA | NO |
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